Which symptom is NOT typically associated with Neuroleptic Malignant Syndrome (NMS)?

Neuroleptic Malignant Syndrome (NMS) is a serious and potentially life-threatening reaction to antipsychotic medications, characterized by a distinctive set of symptoms. Among these are hyperthermia, muscle rigidity, and elevated creatine phosphokinase (CPK) levels. Each of these symptoms reflects the intense physiological stress and muscular dysfunction that occurs during NMS.

Hyperthermia, or elevated body temperature, is a hallmark of NMS and can reach dangerously high levels. Muscle rigidity is also a key symptom, often described as "lead-pipe" rigidity, which can significantly impede movement. Elevated CPK is a result of muscle breakdown, which commonly occurs during NMS due to severe muscle rigidity and increased muscle activity.

In contrast, a severe skin rash is not typically associated with NMS. While skin reactions can occur due to various medications, they do not form part of the classic symptomatology linked with NMS, which is primarily centered around movement abnormalities, autonomic instability, and altered mental status. Thus, the presence of a severe skin rash would not be consistent with the clinical presentation expected in someone experiencing NMS.