What is the leading cause of death among individuals with schizophrenia?

Individuals with schizophrenia are at significantly increased risk for a variety of health issues, but cardiometabolic disease stands out as the leading cause of death in this population. This is largely due to a combination of factors intrinsic to the disorder, such as lifestyle choices, side effects of antipsychotic medications, and the impact of chronic stress on the body.

Patients with schizophrenia often face challenges related to physical health due to factors like smoking, sedentary behavior, poor diet, and lack of access to regular medical care. The antipsychotic medications, while essential for managing symptoms, can also contribute to weight gain, insulin resistance, and changes in lipid metabolism, all of which increase the risk for cardiovascular issues and diabetes.

These cardiometabolic conditions can lead to heart disease, stroke, and other complications, which are among the highest mortality risks in individuals with schizophrenia. While other options such as respiratory disease and accidental injuries do contribute to mortality in this group, they do not match the impact and prevalence of cardiometabolic illnesses.