What is one serious side effect of Clozapine?

Clozapine is known for its efficacy in treating treatment-resistant schizophrenia; however, it carries significant risks, and one of the most serious side effects is agranulocytosis. This condition is characterized by a dangerously low level of neutrophils, which are white blood cells essential for fighting infections. Agranulocytosis can lead to increased susceptibility to infections, which can be life-threatening if not monitored and managed appropriately.

Due to this risk, patients on Clozapine require regular monitoring of their blood counts, particularly during the first six months of treatment when the risk is highest. This monitoring helps ensure any drops in white blood cell counts are detected promptly, allowing for timely intervention.

While weight gain, dry mouth, and visual disturbances are common side effects of many antipsychotics, they are generally less severe than agranulocytosis. Understanding the serious implications of agranulocytosis is crucial for ensuring safe prescribing and patient management practices in mental health nursing.