What is a major concern with the use of clozapine?

Clozapine is a unique antipsychotic medication that is often used to treat treatment-resistant schizophrenia. One of the major concerns associated with its use is its potential for very severe side effects, particularly agranulocytosis, which is a dangerous decrease in white blood cell count. This side effect can lead to increased susceptibility to infections and requires regular monitoring of white blood cell counts during treatment.

In addition to agranulocytosis, clozapine can also cause other serious side effects such as seizures, myocarditis, cardiomyopathy, and metabolic changes. These risks necessitate careful consideration and monitoring, making it crucial for healthcare providers to weigh the benefits against the potential severe adverse effects when prescribing clozapine.

This concern about severe side effects is what distinguishes clozapine from other antipsychotic medications, which may have a different side effect profile. Monitoring protocols and safety precautions are essential in managing the risks associated with its use.